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KMID : 0616120230540010021
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Korean Journal of Pharmacognosy
2023 Volume.54 No. 1 p.21 ~ p.26
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Cirsium japonicum var. Maackii Extract Suppress VCAM-1 and ICAM-1 Expression in TNF-α-treated Human Vascular Endothelial Cells by Blocking NF-κB Activation
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Shin Jae-Young
Cho Byoung-Ok
Park Ji-Hyeon
Kang Eun-Seo
Sim Jae-Suk
Sim Dong-Jun
Jang Seon-Il
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Abstract
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Cirsium japonicum var. maackii is a traditional Korean wild perennial herb used to treat blood circulation, high blood pressure, inflammation, diabetes, and kidney damage. However, it is not known whether C. japonicum var. maackii directly improves endothelial dysfunction. In this study, the effect of C. japonicum var. maackii (CJE) on tumor necrosis factor (TNF)-α-induced vascular inflammation was investigated in vitro using human umbilical vein endothelial cells (HUVEC). As a result, CJE inhibited the production of VCAM-1, ICAM-1 and ROS increased by TNF-α in HUVECs. In addition, treatment with CJE attenuated IκB phosphorylation and translocation of NF-κB to the nucleus. These results suggest that CJE can suppress TNFα-induced adhesion molecule expression by blocking NF-κB signaling and inhibiting ROS generation. The results of this study show that CJE has the potential to be used to treat and prevent inflammation associated with endothelial cell damage.
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KEYWORD
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Cirsium japonicum var. maackii, Endothelial cell injury, Atherosclerosis, ICAM-1, VCAM-1, NF-κB
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